Wednesday, May 22, 2019

Natural Products

graphic products isolated from various sources especially derived from plants, defy long been used in treatment of human ailments. For long time, the approach to innovative do drugss through intrinsic products was proved to be the single most successful approach for the discovery of new drugs.Despite the initial success, chemical diversity and special(prenominal) action on target, drug discovery from natural products, has been deemphasized by many pharmaceutical companies in favour of approaches based on combinatorial chemistry and genomics. Natural products have a oversized unexplored range of compounds, which is almost incredible to imitate, they will always remain a prospective source of future drug discovery (Gurnani et al., 2014).Nature have been explored by people in search of new drugs particularly plants. Medicinal plants have curative properties to treat various diseases ascribable to this reason use the large number. Almost 95 % of the prescriptions were plant based in the traditional system of Unani,Homeopathy,Ayurveda and Siddha in Indian traditions. The study of plants continues principally for the discovery of unique secondary metabolites.Bark, leaves, flowers and seeds ar any part of the plant may contain active compounds, plant products have been holding phytomedicines these can be derived from plant. In recent years, there has been a gradual revival of interest in the use of medicinal plants in developing countries be origin herbal medicines have been reported untroubled and without any adverse side effect especially when compared with synthetic drugs. Thus a search for new drugs with better and cheaper substitutes from plant origin is a natural choice.The medicinal values of these plants lie in some chemical substances that produce a definite physiological action on human body (Savithrama et al., 2011). An aerophilous stress is the result of free radicals, which form stable electron pairing with biological macromolecules such as prot eins, lipids and DNA in healthy human cells and cause protein and DNA damage along with lipid peroxidation.It is answerable for many of todays diseases that results from an imbalance between formation and neutralization of prooxidants. In defense against this oxidative stress, body have their own system including various enzymes, proteins, and vitamins, which are known as antioxidants (Aruna kumari and Sharma 2017).The method of scavenging of DPPH radicals was developed by Blois (1958). The method is rapid, inexpensive, simple, and the results are reproducible. This method has been widely used by various researchers to evaluate free radical scavenging activity of plants (Raghavendra et al., 2017).Bioinformatics is a key factor in rapid growing advanced in genomics, proteomics, medicine, drug origination and development. Bioinformatics has become a very significant part of different areas of biology is tool and technique to aid in the processing extraction and determination of large amount of raw data, textual mining of biological literature, analysis of Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA), Protein structure, Gene expression, Genetic genomic data and help analyze biological pathways that are imperative part of the system biology (Nahla et al., 2016).

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.